Table 2.
SNP analysis of the PADI family.
| PADI family | SNP sites | Disease susceptibility |
|---|---|---|
| PADI2 | rs1005753, rs2057094, rs2076616, rs2235912, rs2235926 | rheumatoid arthritis (33–36) |
| PADI4 | rs11203367, rs2240335, rs2240340, rs1748033, rs874881 rs11203366, rs2240339, SCV000804840, SCV000807675 rs2240335, PADI4 _ 94, PADI _ 104, PADI4 _ 92 ADI4-94G/A, PADI4-92C/G, PADI4-90C/T PADI4 _ 89 × G、 PADI4 _ 90 × T 和 PADI4 _ 92 × G |
rheumatoid arthritis (37–48) |
| rs1635564, rs2240340, rs1929992 | systemic lupus erythematosus (49, 50) | |
| rs11203366, rs11203367, rs874881, rs2240340, rs11203368 | systemic lupus erythematosus lupus nephritis (49) |
|
| rs10437048, rs41265997, rs2501796, rs2477134 | esophageal cancer (51) | |
| rs874881, rs11203366, rs11203367, rs2240339 SCV000804840, SCV000807675 |
osteoarthritis (40) | |
| rs1748033 | autoimmune thyroid diseases (52) | |
| rs1635566, rs882537 | gastric carcinoma (53) | |
| rs2240337G > A, rs11203366, rs1886302, rs1635562, rs1635564, rs2477137 |
esophageal squamous cell carcinoma (54) |