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. 2023 Mar 20;17:1112206. doi: 10.3389/fnsys.2023.1112206

FIGURE 3.

FIGURE 3

Cortical and subcortical regions involved in the pain-related neuromatrix (created with BioRender.com). In healthy subjects and MCS or LIS patients the functional connections (red lines) are preserved whereas in “true” UWS patients the somatosensory cortex is activated in isolation [based on Bouhassira et al. (2005) and Bagnato et al. (2021)].