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. 2023 Mar 20;10:1155521. doi: 10.3389/fmolb.2023.1155521

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Copyright © 2023 Kohler and Andréasson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simplified comparison between different disaggregation machineries. While bacteria, fungi and plants rely of disaggregation based on the activity of a Hsp100 isoform, supported by Hsp70, Hsp110 and a diverse set of J-domain proteins (JDP), metazoan disaggregation is based on Hsp70 activity, supported by co-chaperones belonging to the Hsp110 and JDP class. Please note that additional chaperones and protein quality control factors are involved to guarantee efficient disaggregation.