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. 2023 Mar 20;14:1148412. doi: 10.3389/fendo.2023.1148412

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Copyright © 2023 Meng, Nan, Li, Ding, Yin and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CRISPR gene knockout tool for screening immunotherapy-related genes. (A) By knocking out the ILK gene, cancer cells become more sensitive to immune cells. The expression of ILK is correlated with the expression level of PD-L1, which can be used as a therapeutic target for PD-L1-related immune escape. (B) In the prophylactic tumor inoculation model, the number of immunogenic necrotic cells was higher than that of apoptotic cells after AH1 knockdown. Necrosis may be the preferred form of ICD in cancer therapy. (C) SIAE is a gene that regulates the acetylation of Neu5AC. SIAE gene knockout can improve the acetylation level of Neu5AC and enhance the killing ability of NK cells. (D) TRAIL can kill CD133-positive tumor stem cells and reduce the number of M2 macrophages. The expression level of CD133 decreased after treatment. TRAIL can be used as a therapeutic drug for CD133 (+) tumor stem cells.