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. 2023 Apr 1;9:110. doi: 10.1038/s41420-023-01407-z

Fig. 2. Relevant targets and their interactions for targeting ferroptosis for lung cancer therapy.

Fig. 2

GPX4 glutathione peroxidase 4, SLC3A2 solute carrier family 3, member 2, SLC7A11 solute carrier family 7 (L-type amino acid transporter), member 11, RBMS1 RNA-binding protein, SOX2 stem cell transcriptional factor, AKR1B1 aldo-keto reductase family 1 member B1, STAT3 activator of transcription 3, METTL3 methyltransferase-like 3, CCT3 chaperonin containing TCP1 subunit 3, Nrf2 nuclear factor erythroid 2-related factor 2, GCL glutamate-cysteine ligase, γGC gamma-glutamylcysteine, MIB1 E3 ubiquitin ligase, p53 tumor suppressor protein, SAT1 spermidine/spermine N1-acetyltransferase 1, GLS2 glutaminase 2, FSP1 ferroptosis inhibitor protein 1, NFS1 NFS1 cysteine desulfurase, STYK1 Serine-threonine tyrosine kinase 1, LSH Lymph-specific helicase, GINS4 a member of GINS family proteins, Yap Yes associated transcriptional regulator, TFR1 transferrin receptor, FTH ferritin heavy chain, FTL ferritin light chain, BECN1 ecombinant human autophagy effector protein, USP7 ubiquitin-specific processing protease 7, USP11 ubiquitin-specific processing protease 11, CRL4DCAF8 cullin-RING E3 ligase complex, YTHDC2 N6-methyladenosine (m6A) RNA binding protein, A20 ubiquitin-regulated enzyme, SENP1 Small ubiquitin-like modifier specific protease 1, Notch3 the third subtype of Notch family, PRDX6 peroxiredoxin 6, CERK ceramide kinaseCeramide kinase, VDAC voltage-dependent anion-selective channel, MMP mitochondrial membrane potential, miRNA MicroRNA, circRNA Circular RNA, lncRNA Long non-coding RNA, METTL3 methyltransferase-like 3, FABP3 fatty acid binding protein 3, ELAVL1 RNA-binding protein, CBS cystathionine β-synthase, G3BP1 Ras GTPase activating protein binding protein 1.