Gint4.T-STAT3 effect on spheroid cultures
(A) Spheroids were derived from Calu-1 cells left untreated or treated with 400 nmol/L Gint4.T-STAT3. (B) Spheroids were derived from Calu-1 cells (−) or Calu-1 mixed with CAF#17 (ratio 1:4) in the absence or in the presence of 400 nmol/L Gint4.T-STAT3. In (A) and (B), left panels, representative photographs are shown; right panel, boxplots showing the range of spheroid diameter distribution (>50 μm) with median size. Statistics reported: (A) ∗∗∗p < 0.001 by nonparametric Mann-Whitney U test; (B) ∗p < 0.05; ∗∗∗p < 0.001 by nonparametric Kruskal-Wallis test with multiple comparison correction.