Table V.
Maternal outcome in singleton pregnancies after preimplantation genetic testing (PGT), IVF/ICSI, and spontaneous conception (SC) in Sweden 1996–2019.
| Crude odds ratio (95% CI) | Adjusted odds ratioa (95% CI) | Crude odds ratio (95% CI) | Adjusted odds ratioa (95% CI) | ||||
|---|---|---|---|---|---|---|---|
| PGT | IVF/ICSI | Spontaneous conception | PGT versus IVF/ICSI | PGT versus IVF/ICSI | PGT versus SC | PGT versus SC | |
| Deliveries, n | 390 | 61 060 | 42 034 | ||||
| HDP, n (%) | 17 (4.4) | 3643 (6.0) | 1986 (4.7) | 0.72 (0.44–1.17) | 0.98 (0.60–1.61) | 0.92 (0.56–1.50) | 0.98 (0.60–1.61) |
| PE, n (%) | 8 (2.1) | 2562 (4.2) | 1191 (2.8) | 0.48 (0.24–0.96) | NAc | 0.72 (0.36–1.45) | NAc |
| Placenta praevia, n (%) | 10 (2.6) | 1119 (1.8) | 156 (0.4) | 1.41 (0.75–2.65) | 1.21 (0.64–2.28) | 7.06 (3.70–13.50) | 6.46 (3.38–12.37) |
| Placental abruption, n (%) | <3 (<0.8)b | 437 (0.7) | 157 (0.4) | NAc | NAc | NAc | NAc |
| PPH, n (%) | 27 (6.9) | 4509 (7.4) | 2540 (6.0) | 0.93 (0.63–1.38) | 1.02 (0.68–1.52) | 1.16 (0.78–1.71) | 1.17 (0.78–1.74) |
HDP, hypertensive disorders in pregnancy; PE, pre-eclampsia; PPH, postpartum haemorrhage.
Maternal outcomes included hypertensive disorders in pregnancy (ICD-9 codes 642A–B, 642D, 642X, 642E–H, ICD-10 codes O13–O15), placenta praevia (ICD-9 codes 641A–B, ICD-10 code O44), placental abruption (ICD-9 code 641C, ICD-10 code O45), postpartum haemorrhage (ICD-9 codes 666A–D, ICD-10 code O67.8 and O72).
Bold values indicate a statistically significant result.
Adjustment was made for maternal age, parity, year of birth of child, and for PGT versus IVF/ICSI also for fresh or frozen transfer. Adjustment was also made for BMI in the analysis of HDP, PPH, and Caesarean delivery.
The exact numbers are not reported to ensure anonymity of the participants.
Not applicable. Numbers too small (<10 in the PGT group) to calculate a stable estimate.