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. 2023 Feb 27;42(7):e110496. doi: 10.15252/embj.2021110496

Figure 5. eIF4E overexpression drives widescale reprogramming of splicing.

Figure 5

  1. Left. Dot plot showing the distribution of Inclusion Level Differences (IncLevDiff) values (IncLev (2FLAG‐eIF4E) – IncLev (Vector)) for each splicing category. Right. Histogram showing the number of events for each splicing category.
  2. Splicing heatmap showing the values of IncLev for all the Skipping exon (SE) events between Vector (n = 3, biological replicates) and 2FLAG‐eIF4E (n = 3, biological replicates) U2OS cells. Other events are shown in Appendix Fig S3.
  3. Protein interaction networks identified for alternatively spliced genes. Pathway and process enrichment analysis was applied for each MCODE component, and the best‐scoring term by P‐value is shown.