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Effect of changes in the mRNA levels of total vascular endothelial growth factor (VEGF) and its isoforms (VEGF-120, 164, 188) on tubular long-term HIF-2α overexpression in CKD mice. The mRNA levels of VEGF and its isoforms were determined via qPCR of RNA from the kidneys of standard diet-fed control mice, and 6-week DOX + 0.2% adenine diet-fed WT and Tg mice. *P < 0.05, **P < 0.01, and ***P < 0.001 compared to the controls; #P < 0.05, ##P < 0.01 and ###P < 0.001 between the two groups.
