Table 1.
In vitro efficacy of ensitrelvir in cell lines compared with that of nirmatrelvir, remdesivir and NHC
| Cells | SARS-CoV-2 | Assay | Ensitrelvir | Nirmatrelvir | Remdesivir | NHC |
|---|---|---|---|---|---|---|
| VeroE6/TMPRSS2 | WK-521 | qRT–PCR EC90 (nmol/L) |
91.1 ± 26.4 | 1320 ± 150 | 906 ± 243 | 606 ± 128 |
| VeroE6/TMPRSS2 + P-gp inhibitor | WK-521 | qRT-PCR EC90 (nmol/L) |
33.3 ± 2.7 | 21.5 ± 4.0 | 17.5 ± 3.2 | 1450 ± 130 |
| HEK293T/ACE2-TMPRSS2 | WK-521 | CPE EC50 (nmol/L) |
27 ± 2 | 41 ± 13 | 12 ± 2 | 4000 ± 3500 |
Results are presented as mean ± SD calculated from three independent experiments.
+P-gp inhibitor, 0.75 µmol/L CP-100356.