Table 2.
In vitro efficacy of ensitrelvir in human airway epithelial cells compared with that of nirmatrelvir, remdesivir and NHC
| Cells | SARS-CoV-2 | Assay | Day (p.i.) | Ensitrelvir | Nirmatrelvir | Remdesivir | NHC |
|---|---|---|---|---|---|---|---|
| MucilAir (nasal) | Delta | Viral titre | 2 | 51.4 ± 18.2 | 32.9 ± 2.9 | 35.9 ± 9.7 | 3830 ± 890 |
| EC90 (nmol/L) | 3 | 117 ± 26 | 46.8 ± 10.2 | 35.9 ± 14.0 | 6720 ± 3910 | ||
| MucilAir (nasal) | Omicron(BA.1) | Viral titre | 1 | 66.0 ± 12.5 | 37.6 ± 17.2 | 8.97 ± 6.64 | 2350 ± 890 |
| EC90 (nmol/L) | 2 | 160 ± 57 | 69.2 ± 14.1 | 21.1 ± 9.0 | 3660 ± 920 |
Results are presented as mean ± SD calculated from three independent experiments.