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. 2023 Feb 10;78(4):946–952. doi: 10.1093/jac/dkad027

Table 3.

Protein binding rate of ensitrelvir and nirmatrelvir in mice and hamsters

Animal Protein binding rate (%)
Ensitrelvir Nirmatrelvir
Mouse 97.6 33.1
Hamster 98.3 40.4