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In vivo dose-fractionation study of aztreonam/nacubactam against a neutropenic murine model of thigh infection with NDM-1-positive K. pneumoniae ATCC BAA-2473 (mean ± SD, n = 3). Aztreonam was administered every 2 h, and nacubactam was administered with variable frequency: every 2 h, every 4 h and every 8 h.
