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. 2022 Dec 19;21(4):374–385. doi: 10.1158/1541-7786.MCR-22-0474

Figure 1.

Figure 1. Distinct mutational landscape of PTs and matched BMs. A, Comparison of the mutational landscape between primary lesions and matched BMs. The top panel represents the TMB of each sample. The middle panel represents the matrix of alterations in a selection of frequently mutated genes. Columns represent samples. Three clinicopathologic characteristics (sex, smoking history, and histology) are presented below. B, The cosine similarity of mutational profiles in primary lesions and their matched BMs was calculated. C, Proportions of private and shared alterations of primary and metastatic lesions of patient.

Distinct mutational landscape of PTs and matched BMs. A, Comparison of the mutational landscape between primary lesions and matched BMs. The top panel represents the TMB of each sample. The middle panel represents the matrix of alterations in a selection of frequently mutated genes. Columns represent samples. Three clinicopathologic characteristics (gender, smoking history, and histology) are presented below. B, The cosine similarity of mutational profiles in primary lesions and their matched BMs was calculated. C, Proportions of private and shared alterations of primary and metastatic lesions of patients.