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. 2022 Dec 19;21(4):374–385. doi: 10.1158/1541-7786.MCR-22-0474

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 4. The timing of dissemination and clonal evolution analysis. A, Estimated time of metastatic seeding (Ts) for metastases in each cohort. B, Distribution of trunk and branch variants in each sample. Trunk variants encompassed those that occurred on the root node and its only child node; all others were classified to have occurred in the branch. C, Genes associated with lung cancer in each sample. — The timing of dissemination and clonal evolution analysis. A, Estimated time of metastatic seeding (Ts) for metastases in each cohort. B, Distribution of trunk and branch variants in each sample. Trunk variants encompassed those that occurred on the root node and its only child node; all others were classified to have occurred in the branch. C, Genes associated with lung cancer in each sample.