Distinct genomic landscape of PTs and matched BMs. A, Comparison of the genomic landscape between primary lesions and their matched BMs. B, Comparison of wGII between primary lesions and their matched BMs. C, ITH analysis in primary lesions and matched BMs. D, SDI analysis in primary lesions and matched BMs. E, The cosine similarity of mutational profiles in primary lesions and matched BMs was calculated. F, Proportions of alterations private to the primary or metastatic lesion or shared by primary and metastatic lesions in each tumor specimen. G–H, Comparison of CNA burden between primary lesions and matched BMs.