Figure 2.

Scatterplot of the relationship between kidney microvascular PO₂ versus arterial blood oxygen content in anesthetized Sprague-Dawley rats exposed to acute hemodilutional anemia. A significant correlation (y = 0.30x + 6.9, r² = 0.75) is observed between microvascular kidney tissue PO₂ and arterial oxygen content. As arterial oxygen content decreases, microvascular kidney tissue PO₂ decreases proportionally in a linear manner. This data demonstrates the ability of the kidney to translate C_aO₂ into a local regional microvascular PO₂ based on organ blood flow and tissue metabolic requirements. Data from Abrahamson et al., AJP 2020²⁵ (n = 8); Chin et al., CJA 2021 (n = 5);²⁶ and Ragoonanan et al., Anesthesiology 2009³⁶ (n = 5).