Figure 5.
Organ-specific Erythropoietin (EPO) mRNA and systemic EPO versus arterial blood oxygen content in anemic rats. (A) EPO mRNA expression increases exponentially in both kidney tissue and brain tissue as arterial oxygen content decreases (n = 6). Kidney EPO mRNA expression (y = 178590*10−0.018, r2 = 0.71) increases more dramatically than brain EPO mRNA expression (y = 81.72*10−0.007, r2 = 0.57) in severely anemic conditions. (B) Systemic EPO protein concentration increases exponentially (y = 93806*10−0.02, r2 = 0.82) as arterial oxygen content decreases and the severity of anemic status increases (n = 10). Data from Tsui et al. 2011 and 2014.41,54