Table 3.
Statistics of relations among entities in iBKH
| Entity pair | Relation type | Number of relations of the specific type | Total Number |
|---|---|---|---|
| Anatomy-gene relation | Anatomy-Expresses-Gene | 10,388,168 | 12,171,021 |
| Anatomy-Absent-Gene | 2,837,741 | ||
| Anatomy-DSI relation | DSI-Has_Adverse_Effect_On-Anatomy | 3,121 | 4,334 |
| Drug-disease relation | Drug-Palliates-Disease | 390 | 2,717,947 |
| Drug-Treats-Disease | 5,492 | ||
| Drug-Effects-Disease | 5,136 | ||
| Drug-Associates -Disease | 96,458 | ||
| Drug-Inferred_Relation-Disease | 2,589,522 | ||
| Drug-Text_Semantic_Relation-Disease | 50,653 | ||
| Drug-Drug | Drug-Interacts-Drug | 2,682,157 | 2,684,682 |
| Drug-Resembles -Drug | 6,486 | ||
| Drug-Gene | Drug-Targets-Gene | 16,518 | 1,303,747 |
| Drug-Transporter-Gene | 3,066 | ||
| Drug-Enzyme-Gene | 5,241 | ||
| Drug-Carrier-Gene | 853 | ||
| Drug-Downregulates-Gene | 66,994 | ||
| Drug-Upregulates-Gene | 72,361 | ||
| Drug-Associates-Gene | 19,434 | ||
| Drug-Binds-Gene | 11,571 | ||
| Drug-Interacts-Gene | 1,181,492 | ||
| Drug-Text_Semantic_Relation -Gene | 68,429 | ||
| Drug-Pathway | Drug-Associates-Pathway | 3,231 | 3,231 |
| Drug-Side effect | Drug-Causes-side-effect | 163,206 | 163,206 |
| Drug-molecule | Molecule-Is_A-Drug | 8,757 | 8,757 |
| Drug-DSI | DSI-Interacts-Drug | 3,057 | 3,057 |
| Disease-Disease | Disease-Is_A-Disease | 10,529 | 11,072 |
| Disease-Resembles-Disease | 543 | ||
| Disease-Gene | Disease-Associates-Gene | 47,965 | 27,538,774 |
| Disease-Downregulates-Gene | 7,623 | ||
| Disease-Upregulates -Gene | 7,731 | ||
| Disease-Inferred_Relation-Gene | 27,454,631 | ||
| Disease-Text_Semantic_Relation -Gene | 94,759 | ||
| Disease-Symptom | Disease-Presents-Symptom | 3,357 | 3,357 |
| Disease-Pathway | Disease-Associates-Pathway | 1,941 | 1,941 |
| Disease-DSI relation | DSI-Is_Effective_For-Disease | 5,134 | 5,134 |
| Gene-Gene | Gene-Covaries-Gene | 61,690 | 735,156 |
| Gene-Interacts-Gene | 147,164 | ||
| Gene-Regulates-Gene | 265,672 | ||
| Gene-Associates-Gene | 2,602 | ||
| Gene-Text_Semantic_Relation -Gene | 301,752 | ||
| Gene-Pathway | Gene-Reaction-Pathway | 118,480 | 152,243 |
| Gene-Associates-Pathway | 47,742 | ||
| Symptom-DSI | DSI-Has_Adverse_Reaction-Symptom | 2,093 | 2,093 |
| DSI-DSP | DSP-Has_ingredient-DSI | 689,297 | 689,297 |
| DSI-TC | DSI-Has_therapeutic_class-TC | 5,430 | 5,430 |
Abbreviations: DSI = Dietary Supplement Ingredient; DSP = Dietary Supplement Product; TC = Therapeutic Class.