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. 2023 Apr 3;13(15):10353–10366. doi: 10.1039/d3ra00123g

Cytotoxicity (IC50) of tested compounds 7a–c, 9, 11, 13, 15a and 15b on different cell lines.

Compound No. IC50 (μM)
HepG-2 Caco2 MCF-7 WI 38
7a 4.17 ± 0.20 3.16 ± 0.20 31.50 ± 1.4 28.20 ± 1.50
7b 26.80 ± 1.50 33.60 ± 1.70 35.20 ± 1.6 49.80 ± 2.60
7c 3.04 ± 0.20 3.37 ± 0.20 9.59 ± 0.4 25.40 ± 1.90
9 12.20 ± 0.70 47.20 ± 2.30 7.21 ± 0.3 25.40 ± 1.30
11 15.00 ± 0.80 8.55 ± 0.40 3.34 ± 0.2 24.50 ± 1.80
13 1.76 ± 0.10 8.99 ± 0.40 17.70 ± 0.8 11.40 ± 0.60
15a 6.54 ± 0.40 2.33 ± 0.10 4.34 ± 0.2 13.40 ± 0.70
15b 1.62 ± 0.10 0.78 ± 0.04 4.43 ± 0.2 16.80 ± 0.90
Staurosporine 13.60 ± 0.80 8.18 ± 0.70 6.19 ± 0.3 25.20 ± 1.30