Cytotoxicity (IC50) of tested compounds 7a–c, 9, 11, 13, 15a and 15b on different cell lines.
| Compound No. | IC50 (μM) | |||
|---|---|---|---|---|
| HepG-2 | Caco2 | MCF-7 | WI 38 | |
| 7a | 4.17 ± 0.20 | 3.16 ± 0.20 | 31.50 ± 1.4 | 28.20 ± 1.50 |
| 7b | 26.80 ± 1.50 | 33.60 ± 1.70 | 35.20 ± 1.6 | 49.80 ± 2.60 |
| 7c | 3.04 ± 0.20 | 3.37 ± 0.20 | 9.59 ± 0.4 | 25.40 ± 1.90 |
| 9 | 12.20 ± 0.70 | 47.20 ± 2.30 | 7.21 ± 0.3 | 25.40 ± 1.30 |
| 11 | 15.00 ± 0.80 | 8.55 ± 0.40 | 3.34 ± 0.2 | 24.50 ± 1.80 |
| 13 | 1.76 ± 0.10 | 8.99 ± 0.40 | 17.70 ± 0.8 | 11.40 ± 0.60 |
| 15a | 6.54 ± 0.40 | 2.33 ± 0.10 | 4.34 ± 0.2 | 13.40 ± 0.70 |
| 15b | 1.62 ± 0.10 | 0.78 ± 0.04 | 4.43 ± 0.2 | 16.80 ± 0.90 |
| Staurosporine | 13.60 ± 0.80 | 8.18 ± 0.70 | 6.19 ± 0.3 | 25.20 ± 1.30 |