Table 1.
Patient characteristics for supratentorial intraventricular tumors
| Biopsy | Incomplete resection | Complete resection | Total | p-value | ||
|---|---|---|---|---|---|---|
| Overall, n (%) | 13 (22) | 13 (22) | 33 (56) | 59 (100) | ||
| Age, years | Mean | 55.5 | 37.2 | 37.5 | 41.4 | 0.052 |
| < 18 | 2 (15) | 1 (8) | 7 (21) | 10 (17) | ||
| 18–35 | 2 (15) | 6 (46) | 10 (30) | 18 (31) | ||
| 36–50 | 0 (0) | 2 (15) | 4 (12) | 6 (10) | ||
| 51–65 | 3 (23) | 2 (15) | 8 (24) | 13 (22) | ||
| > 65 | 6 (46) | 2 (15) | 4 (12) | 12 (20) | ||
| Sex | Female | 4 (31) | 5 (38) | 19 (58) | 28 (47) | 0.199 |
| Male | 9 (69) | 8 (62) | 14 (42) | 31 (53) | ||
| Clinical presentation | ||||||
| Preoperative KPS, % | < 90 | 5 (38) | 4 (31) | 4 (12) | 13 (22) | 0.412 |
| 90–100 | 8 (62) | 9 (69) | 29 (88) | 46 (78) | ||
| Preoperative symptoms | Hydrocephalic symptoms | 8 (62) | 10 (77) | 19 (58) | 37 (63) | 0.333 |
| Visual symptoms | 4 (31) | 2 (15) | 4 (12) | 10 (17) | ||
| Cognitive dysfunction | 4 (31) | 1 (8) | 3 (9) | 8 (14) | ||
| Ataxia | 1 (8) | 2 (15) | 2 (6) | 7 (12) | ||
| Seizure | 0 (0) | 0 (0) | 4 (12) | 4 (7) | ||
| Incidental, no symptoms/deficits | 3 (23) | 0 (0) | 6 (18) | 9 (15) | ||
| Hydrocephalus at initial diagnosis (MRI) | Yes | 6 (46) | 10 (77) | 19 (58) | 35 (59) | 0.267 |
| No | 7 (54) | 3 (23) | 14 (42) | 24 (41) | ||
| Tumor localization | Lateral ventricles | 7 (54) | 12 (92) | 33 (100) | 52 (88) | 0.175 |
| Anterior horn | 3 (23) | 2 (15) | 12 (36) | 17 (29) | ||
| Posterior horn | 1 (8) | 1 (8) | 5 (15) | 7 (12) | ||
| Inferior horn | 0 (0) | 0 (0) | 5 (15) | 5 (8) | ||
| Body | 0 (0) | 5 (38) | 5 (15) | 10 (17) | ||
| Atrium | 3 (23) | 4 (31) | 6 (18) | 13 (22) | ||
| Third ventricle | 6 (46) | 6 (46) | 8 (24) | 20 (34) | ||
| Therapy | ||||||
| Tumor volume, median cm3 | Preoperative | 3.1 ± 2.8 | 20.1 ± 6.6 | 6.2 ± 5.0 | 9.5 ± 3.3 | *0.001 |
| Postoperative | 3.1 ± 2.8 | 2.3 ± 0.8 | 0.0 ± 0.0 | 0.0 ± 2.3 | *0.001 | |
| Shunting | Permanent shunting | 5 (38) | 4 (31) | 2 (6) | 11 (19) | *0.018 |
| Transient EVD | 0 (0) | 3 (23) | 5 (15) | 8 (14) | 0.211 | |
| Internal shunting with initial biopsy | 5 (38) | 1 (8) | 1 (3) | 7 (12) | ||
| Postoperative shunting | 0 (0) | 4 (31) | 1 (3) | 5 (8) | ||
| Internal shunt | 0 (0) | 1 (8) | 0 (0) | 1 (2) | ||
|
Ventriculoperitoneal shunt |
0 (0) | 3 (23) | 1 (3) | 4 (7) | ||
| Adjuvant therapy | Watch-and-wait | 6 (46) | 8 (62) | 25 (76) | 39 (66) | *0.049 |
| Radiotherapy | 1 (8) | 3 (23) | 4 (12) | 8 (14) | ||
| Radiochemotherapy | 1 (8) | 2 (15) | 3 (9) | 6 (10) | ||
| Chemotherapy | 1 (8) | 0 (0) | 1 (3) | 2 (3) | ||
| Brachytherapy | 2 (15) | 0 (0) | 0 (0) | 2 (3) | ||
| Best supportive care | 2 (15) | 0 (0) | 0 (0) | 2 (3) | ||
Characteristics are given for all patients with supratentorial intraventricular tumors (n = 59) as well as patients receiving biopsy (n = 13), incomplete (n = 13) and complete (n = 33) tumor resection. Of note, one patient undergoing incomplete tumor resection received both, internal shunting with biopsy, followed by VP shunting after resection. Significant differences are indicated by *p ≤ 0.05
Abbreviations: EVD external ventricular drainage, MRI magnetic resonance imaging, KPS Karnofsky Performance Status