Fig. 2.
LRH1 upregulated downstream target genes in PC. (A) Expression levels of c-Myc, MMP2 and MMP9 (in Capan-1) were significantly enhanced in LRH1 overexpressed stable Capan-1 and AsPC-1 cells than vector control and (B) LRH1 expression in stable MIA PaCa2 cells with constitutive expression of specific shRNAs was significantly reduced, and the expression of c-Myc, MMP2 and MMP9 was downregulated in response to LRH1 knockdown.