Table 8.
Associations of preoperative medical/psychological comorbidities with pain/opioid use after THA
| First author | Year | Study design | n | Follow-up | Outcome measures | Associations of preoperative comorbidities with postoperative pain/opioid use |
|---|---|---|---|---|---|---|
| Prentice [9] | 2019 | RC | 12,560 | 1 yr | Opioid usage | Higher postoperative opioid prescriptions with anxiety, chronic pulmonary disease, substance abuse, acquired immunodeficiency syndrome (AIDS), peripheral vascular disease, chronic blood loss anemia, congestive heart failure |
| Bedard [11] | 2017 | RC | 37,393 | 1 yr | Opioid use | Higher risk postoperative opioid use with preoperative anxiety, depression, drug use, alcohol use, smoking |
| Brembo [12] | 2017 | PC | 223 | 3 mo | WOMAC | Worse pain with increased medical comorbidities |
| Dowsey [15] | 2016 | PC | 382 | 1 and 2 yr | HHS | Worse pain with poor mental function |
| Greene [17] | 2016 | RC | 17,147 | 1 yr | VAS for pain | Worse pain if using antidepressants |
| Rajamaki [21] | 2015 | PC | 54 | 1–2 yr | NRS | Greater odds of pain in diabetes |
| Lavernia [25] | 2014 | RC | 60 | 11 (3–24) mo | HHS | Worse pain in vitamin D insufficiency |
| Petrovic [27] | 2014 | CC | 90 | 1 d | NRS | Higher odds of pain in type D personality, anxiety, depression |
| Dowsey [22] | 2014 | PC | 835 | 1 yr | HHS | Worse pain with increased medical comorbidities |
| Pinto [32] | 2017 | CC | 48 | 4–6 mo | NRS | Worse pain with poor disease process perception and emotional representation |
| Judge [2] | 2013 | PC | 1431 | 1–5 yr | OHS | Worse pain in medical comorbidities |
| Singh [34] | 2013 | PC | 5707, 3289 | 2 yr, 5 yr | VAS for pain | No association |
| Jones [35] | 2012 | PC | 231 | 3 yr | WOMAC | Worse pain with cardiac disease |
| Smith [37] | 2012 | PC | 1318 | 3 yr | HHS | Worse pain with cardiac disease, hypertension, increase medical comorbidities, NSAID use |
| Allen Butler [38] | 2011 | PR | 119 | 2 yr | VAS, HHS, SF-12 | Worse pain with poor mental component score |
| Singh [46] | 2010 | PC | 5707, 3289 | 2 yr, 5 yr | Pain medication use | Greater odds of pain, NSAID use, and opioid use in depression |
| Riediger [44] | 2010 | PC | 79 | 8 wk | WOMAC, SF-36 | Worse pain in depression and somatoform disorders |
| Rolfson [49] | 2009 | RC | 6158 | 1 yr | VAS for pain | Worse pain in anxiety and depression |
ASA American Society of Anesthesiologists, CAD Coronary artery disease, CC Case–control, CCI Charlson Comorbidity Index, CI Confidence interval, HHS Harris Hip Score, HTN Hypertension, NRS Numerical rating scale, NSAID Nonsteroidal anti-inflammatory drug, OHS Oxford Hip Score, OR Odds ratio, PC Prospective cohort, PR Prospective randomized, RC Retrospective cohort, SF-12 12-Item Short-Form Health Survey, SF-36 36-Item Short-Form Health Survey, VAS 10-cm visual analog scale, WOMAC Western Ontario and McMaster Universities Arthritis Index