Table 2.

The effect of smoking on the efficacy of dual antiplatelet therapy for prevention of subsequent ischemic stroke in the full cohort and subgroups stratified by age, gender, race, and type 2 diabetes mellitus status.

	Smoker			Non-smoker
	Number of patients	Hazard ratio (95% CI)	p-Value	Number of patients	Hazard ratio (95% CI)	p-Value
Total population	1004	0.63 (0.37, 1.05)	0.078	3873	0.74 (0.56, 0.98)	0.030
Subgroups
Age, years
<60	573	0.52 (0.26, 1.05)	0.067	1140	1.09 (0.63, 1.89)	0.756
⩾60	431	0.81 (0.36, 1.80)	0.599	2733	0.65 (0.47, 0.90)	0.009
Gender
Female	368	0.73 (0.31, 1.71)	0.466	1825	0.62 (0.41, 0.93)	0.020
Male	636	0.57 (0.30, 1.10)	0.096	2048	0.87 (0.60, 1.27)	0.469
Race
Black	284	0.28 (0.10, 0.84)	0.023	681	0.73 (0.43, 1.24)	0.250
White	651	1.10 (0.57, 2.14)	0.78	2902	0.77 (0.55, 1.08)	0.128
T2DM status
Has T2DM	222	0.86 (0.26, 2.83)	0.808	1115	0.78 (0.51, 1.19)	0.242
No T2DM	776	0.58 (0.33, 1.04)	0.077	2755	0.71 (0.49, 1.02)	0.064