Box 2.

QASC Europe outcome measures.

• Primary outcome (Post-hoc)* ■ Adherence to all monitoring and treatment elements of the FeSS Protocols • Secondary outcomes ■ Adherence to all monitoring and treatment elements of the Fever Protocol ■ Adherence to all monitoring and treatment elements of the Hyperglycaemia (Sugar) Protocol ■ Adherence to all monitoring and treatment elements of the Swallow Protocol • Tertiary outcomes ■ Fever Protocol  ○ Temperature monitored at least four times per day on day of admission  ○ Temperature monitored at least four times per day on day 2 of admission  ○ Temperature monitored at least four times per day on day 3 of admission  ○ Paracetamol (or other anti-pyretic) given for first temperature ⩾37.5°C  ○ Paracetamol (or other anti-pyretic) given with 1 h from first temperature ⩾37.5°C ■ Hyperglycaemia (Sugar) Protocol  ○ Venous blood glucose level sample collected and sent to laboratory  ○ Blood Glucose Levels (BGL) monitored at least four times per day on day of admission  ○ BGLs monitored at least four times per day on day 2 of admission  ○ BGLs monitored at least four times per day on day 3 of admission (if BGLs unstable)  ○ Insulin given for first BGL ⩾10 mmol/L  ○ Insulin given within 1 h from first BGL ⩾10 mmol/L ■ Swallow Protocol  ○ Formal swallow screen performed  ○ Failed screen and subsequently had swallow assessment  ○ Swallow screen performed within 24 h  ○ Swallow assessment recorded  ○ Swallow screen OR assessment recorded  ○ Swallow screen or assessment performed before being given oral medications  ○ Swallow screen or assessment performed before being given oral food or fluids ■ Treatment Outcomes (Post-hoc)*  ○ Receipt of thrombolysis  ○ Stroke unit care ■ Discharge Outcomes (Post-hoc)*  ○ Discharge destination  ○ Ability to walk on discharge  ○ Duration of hospital stay  ○ Discharge modified Rankin Score

^*Post-hoc outcomes were determined prior to analysis.