Fig. 1.

Possible shared pathophysiological mechanisms in migraine and preeclampsia. Preeclampsia and migraine share overlapping pathophysiology, including inflammation and endothelial dysfunction. Like migraine, the cerebral effects of preeclampsia include neuroinflammation, alterations in angiogenic pathways, endothelial cell dysfunction, changes in vascular reactivity, blood–brain barrier dysfunction, and platelet activation. This may account for the epidemiological association between migraine and risk of preeclampsia; however, the specific mechanisms of this association are not well understood. Figure created with BioRender.com