Tab. 1:

Hub and Lung KEs/AOPs

Hub KEs	KE1738	Susceptibility to viral entry, increased
	KE1739	ACE2 binding to viral S-protein
	KE1847	Coronavirus production, increased
	KE1854	ACE2 dysregulation
Hub AOPs	AOP379	Increased susceptibility to viral entry and coronavirus production leading to thrombosis and disseminated intravascular coagulation
	AOP392	Bradykinin and fibrinolytic dysregulation, hyperinflammation
Lung AOPs	AOP320	Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress (ARDS) associated mortality
	AOP377	TLR9 activation leading to ARDS and Multi Organ Dysfunction
	AOP173	Substance interaction with the lung resident cell membrane components leading to lung fibrosis
	AOP319	Inhibition of Angiotensin-converting enzyme 2 leading to lung fibrosis
	AOP302	Lung surfactant function inhibition leading to decreased lung function