Table 1.
Baseline characteristics, clinical manifestations and outcomes of the eight SOT recipients with AE.
| ID | Sex; F: female; M: male | Age at diagnosis | Transplanted organ | Time from transplant to diagnosis (in months)a | Immunosuppressive regimen | Clinical presentation | Extension | PNM stage | Diagnostic delayb (in months) | Comments |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 57 | Lung | 43 | Prednisone, MMF, Tacrolimus | Asymptomatic | – | P1N0M0 (I) | 1 | |
| 2 | F | 53 | Kidney (2×) | 12a | Prednisone, Tacrolimus | Fever and pain in left hypochondrium | Stomach and esophagus | P1N1M0 (IIIb) | – | |
| 3 | M | 55 | Kidney | 91 | MMF, Everolimus | Pain in right hypochondrium | – | P2N0M0 (I) | 11 | Radiological lesions not immediately investigated |
| 4 | F | 62 | Kidney (2×) | 240a | Prednisone, cyclosporine, azathioprine (switched to MMF) | Asymptomatic | – | P1N0M0 (I) | 30 | Radiological lesions not immediately investigated |
| 5 | F | 66 | Heart | 117 | Prednisone, MMF, cyclosporine | Epigastric pain | Head of pancreas | P4N1M0 (IV) | – | |
| 6 | F | 59 | Kidney | 57 | MMF, Tacrolimus | Asymptomatic | – | P0N0M1 (IV) | 12 | Initial misdiagnosis of tuberculosis |
| 7 | M | 36 | Kidney | 75 | Prednisone, MMF, Cyclosporine | Asymptomatic | – | P1N0M0 (I) | 3 | Initial misdiagnosis of metastasis |
| 8 | F | 43 | Lung | 12 | Prednisone, MMF, Tacrolimus | Pain in right hypochondrium | – | P1N1M0 (IIIb) | – |
a
Time from the first transplantation to diagnosis.
b
Time from first evidence of a radiological lesion to final diagnosis. MMF: MycoPhenolate Mofetil.