Table 3.
Treatment, follow-up and outcome of AE in patients with solid organ transplantation.
| Treatment and outcome |
Follow-up |
|||||
|---|---|---|---|---|---|---|
| ID | Surgical intervention (months from diagnosis) | Albendazole | Outcome | Follow-up (months) | Follow-up serology | Follow-up imaging |
| 1 | Incomplete resection (0 m) | No | Deceaseda | 0 | – | – |
| 2 | Incomplete resection (0 m) | 400 mg bid | Stabilization | 43 | Negative at 19 and 42 months b | MRI at 32 and 43 months: stabilization |
| 3 | No | 400 mg bid, increased to 400 mg tid (due to the progression) | Progression | 49 | EgHF ELISA (at 17 and 30 m): positive, titers decreasing | PET-CT (at 32 and 49 m): persistence of metabolic activity; progression |
| AE serology b (at 17 and 30 m): positive, titers increasing | MRI at 44 months: progression | |||||
| Western blot (at 17 and 30 m): positive | ||||||
| 4 | Incomplete resection (31 m) | 400 mg bid, increased to 400/600 mg | Deceaseda | 31 | – | – |
| 5 | No | 400 mg bid | Deceased | 5 | – | – |
| 6 | Incomplete resectionc (2 months prior diagnosis) | 400 mg bid | Stabilization | 20 | Serologyb titers decreasing at 18 and 20 months | Chest CT-scan at 6 and 12 months: no new lesion |
| 7 | No | 400 mg bid | Stabilization | 48 | Eg IHA and ELISAb at 3, 6, 18, 24, 30, 36 and 48 months: decreasing titers (rebound of IHA at 30 m, then decrease) | MRI at 18 and 48 months: stabilization |
| 8 | Complete resection (14 m) | 400 mg bid, decreased to 200 mg bid (supra-therapeutic concentration) | Regression | 42 | EgHF ELISA (0 and 4 m): decreasing titers | MRI (9 m): no lesion |
| Em2+ ELISA (0, 4, 6 m): decreasing titers; negative at 42 m | PET-CT : 1 month: residual metabolic activity; 13 and 42 m : no metabolic activity | |||||
| Eg IHA (0, 4 and 6 m): neg, neg, pos | ||||||
| Western blot (0, 4 and 6): pos, neg, pos | ||||||
a
Died of peri-operative complications;
b
The type of assay or the antigen is unknown. AE: Alveolar Echinococcosis; IHA: Indirect HemAgglutination.
c
The resection was performed for diagnostic purpose. MRI: Magnetic Resonance Imaging; CT: Computed Tomography; PET-CT: Positron Emission Tomography associated with Computed Tomography.