Table 4.
Perioperative surgical outcomes for patients who received or did not receive a direct oral anticoagulant
| Study | Time to surgery, mean ± SD (range), h | Surgical duration, mean ± SD,* h | Change in postoperative hemoglobin level, mean ± SD (range), g/L | Change in postoperative hemoglobin level, mean, % | pRBC transfusion, no. of patients | 30-day mortality, no. of patients | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
|
|
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| Control | DOAC | Control | DOAC | Control | DOAC | Control | DOAC | Control | DOAC | Control | DOAC | |
| Schermann et al.,20 2019 | ||||||||||||
|
| ||||||||||||
| CRIF | 31.2 ± 22.2 | 40.2 ± 26.9 | 110.7 ± 48.9 | — | NR | NR | 24.0 | 22.6 | 77 | 5 | 43 | 4 |
|
| ||||||||||||
| HA | 36.3 ± 25.8 | 42.3 ± 27.3 | 126.2 ± 39.8 | — | NR | NR | 21.0 | 21.7 | 36 | 3 | 30 | 2 |
|
| ||||||||||||
| Schuetze et al.,29 2019 | 8.2 (1.3–23.9) | 9.5 (2.3–24.0) | NR | NR | NR | NR | NR | NR | 24 | 20 | NR | NR |
|
| ||||||||||||
| Franklin et al.,14 2018 | 21.4 ± 12.4 | 28.9 ± 11.8 | 93.5 ± 44.2 | 82.7 ± 37.9 | 30 ± 2.0 | 32 ± 1.4 | NR | NR | 6 | 25 | 12 | 1 |
|
| ||||||||||||
| Mullins et al.,27 2018 | 19 (3–44)* | 19 (7–64)* | NR | NR | 23 (1–47) | 23 (0–49) | NR | NR | 6 | 11 | 5 | 1 |
|
| ||||||||||||
| Weighted total, no. (%) | 30.2† | 29.3† | 114.8 | 120.9 | 29.2 | 29.3 | 23.0 | 22.3 | 149 (8.6) | 64 (29.1) | 90 (5.6) | 8 (4.7) |
CRIF = closed reduction internal fixation; DOAC = direct oral anticoagulant; HA = hemiarthroplasty; NR = not recorded; pRBC = packed red blood cells; SD = standard deviation.
*
Reported as median and range.
†
Weighted mean does not include the study by Mullins and colleagues.27