Table 1. MR results of LTL on risk of BD.
| Exposure | Method | No. of SNPs | OR (95% CI) | P | P-het | P-intercept |
|---|---|---|---|---|---|---|
| MR Egger | 133 | 0.641 (0.438–0.939) | 0.024 | 0.001584 | 0.173404 | |
| IVW | 133 | 0.800 (0.647–0.989) | 0.039 | 0.001255 | ||
| LTL | Maximum likelihood | 133 | 0.799 (0.668–0.956) | 0.014 | ||
| MR-PRESSO (RAW) | 133 | 0.800 (0.646–0.991) | 0.041 | |||
| MR-RAPS | 133 | 0.798 (0.667–0.955) | 0.014 |
Notes.
- MR
- Mendelian randomization
- LTL
- leukocyte telomere length
- BD
- bipolar disorder
- IVW
- inverse variance weighted
- MR-PRESSO
- Mendelian randomization-pleiotropy residual sum outlier
- MR-RAPS
- MR-robust adjusted profile score
- OR
- odds ratio
- P-het
- P value for heterogeneity using Cochran Q test
- P-intercept
- P value for MR-Egger intercept
- SNP
- single-nucleotide polymorphism