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. Author manuscript; available in PMC: 2023 Apr 3.
Published in final edited form as: J Physiol. 2022 Oct 13;600(21):4633–4651. doi: 10.1113/JP283581

Figure 3. Plasma trimethylamine N-oxide (TMAO).

Figure 3.

Plasma TMAO may increase with age in control mice (P = 0.066) but is lower in mice supplemented with 3,3-dimethyl-1-butanol (DMB) at 27 months of age. Plasma was collected from mice at the time the mice were euthanized and TMAO levels were determined via liquid chromatography-tandem mass spectrometry. Data are mean ± SD n = 9–22 per group. Statistics are one-way (effect of age in control mice only) ANOVA with Dunnett’s post hoc test and two-way mixed (age × treatment group) ANOVA with Šídák’s post hoc test. *P < 0.05 DMB vs. control within time point.