Baumslag 1970.
Methods | This was a randomised trial conducted on all pregnant women who were attending antenatal clinics at the Baragwanath and South Rand Hospitals, Johannesburg (South Africa). Pregnant women were allocated into 3 interventions groups based on random numbers. | |
Participants | All pregnant women attending antenatal clinics at Baragwanath and South Rand Hospitals, Johannesburg (n = 355). | |
Interventions | Group 1 received 200 mg of iron by mouth (n = 115). Group 2 received 5 mg of folic acid daily by mouth in addition to the iron (n = 127). Group 3 received 50 µg of vitamin B12 by mouth in addition to the folic acid and iron (n = 113). |
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Outcomes | Birthweight was measured. | |
Notes | Birthweight was analysed separately for Bantu participants and white participants. In the white participants supplementation was started after the 24th week, while supplementation in Bantu participants was started after 28th week. We compared the data of group 1 with group 2 only. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Quote: "patients were allocated by random numbers to three groups". |
Allocation concealment (selection bias) | Unclear risk | Insufficient information about allocation concealment. |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Insufficient information about blinding. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Insufficient information about exclusion and attrition. |
Selective reporting (reporting bias) | Low risk | The study has mentioned data on all outcome measure mentioned as objective. |
Other bias | Unclear risk | No other bias identified but insufficient information available to fully assess this 'Risk of bias' domain. |