Blot 1981.
Methods | This was a RCT conducted on women coming for antenatal examination in Paris. Each women was given a bottle containing iron or a combination thereof with folic acid. The 2 groups of women were totally comparable on their baseline characteristics. | |
Participants | All women attending for the compulsory antenatal examination at the end of 6th month of pregnancy (n = 109). | |
Interventions | Group1: iron 105 mg (n = 55). Group2: iron 105 mg + folic acid 350 mg (n = 54). |
|
Outcomes | Pre‐delivery haemoglobin levels (n = 109). | |
Notes | All women were given ascorbic acid 500 mg. Study population was generally from upper social class which may lead to underestimation of nutritional deficiencies. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Quote: "patients were given bottle of 90 tablets, contained either iron or the combination of iron with folic acid". Comment: probably not done. |
Allocation concealment (selection bias) | Low risk | Bottle of tablets without the awareness of intervention type was given to patients. |
Blinding (performance bias and detection bias) All outcomes | Low risk | Neither the patient nor the obstetrician was aware of the nature of treatment. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Data on exclusion with its reason were not described in the text. Attrition (45.5%) with reasons were reported. |
Selective reporting (reporting bias) | Low risk | Study appears to be free of selective reporting. |
Other bias | Unclear risk | No other bias identified but insufficient information available to fully assess this 'Risk of bias' domain. |