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. 2013 Mar 28;2013(3):CD006896. doi: 10.1002/14651858.CD006896.pub2

Decsi 2005.

Methods This is a placebo‐controlled, randomised, double‐blind trial on expecting mothers living in Germany, Hungary and Spain.
Participants Expectant women from the 20th week of gestation (n = 312).
Interventions Women received either:
Group A: 500 mg Docosahexaenoic Acid (DHA) (n = 77)
Group B: or 400 mg Methyltetrahydofolate (5‐MTHF) (n = 80)
Group C: or placebo (n = 80)
Group D: or the combination of 500 mg DHA and 400 mg 5‐MTHF (n = 75).
Outcomes Contribution of docosahexaenoic acid (DHA) to the fatty acids of erythrocyte phophatidylcholine (PC) and phosphatidylethanolamine (PE) lipids at delivery (n = 312).
Notes For this review, we compared group B with group C. and group A with group D.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "....randomized,..."
Comment: insufficient information to permit judgment.
Allocation concealment (selection bias) Unclear risk Insufficient information to permit judgment.
Blinding (performance bias and detection bias) 
 All outcomes Low risk Quote: "....double blind,..."
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Insufficient information to permit judgment.
Selective reporting (reporting bias) Unclear risk Insufficient information to permit judgment.
Other bias Unclear risk No other bias identified but insufficient information available to fully assess this 'Risk of bias' domain.