Decsi 2005.
Methods | This is a placebo‐controlled, randomised, double‐blind trial on expecting mothers living in Germany, Hungary and Spain. | |
Participants | Expectant women from the 20th week of gestation (n = 312). | |
Interventions | Women received either: Group A: 500 mg Docosahexaenoic Acid (DHA) (n = 77) Group B: or 400 mg Methyltetrahydofolate (5‐MTHF) (n = 80) Group C: or placebo (n = 80) Group D: or the combination of 500 mg DHA and 400 mg 5‐MTHF (n = 75). |
|
Outcomes | Contribution of docosahexaenoic acid (DHA) to the fatty acids of erythrocyte phophatidylcholine (PC) and phosphatidylethanolamine (PE) lipids at delivery (n = 312). | |
Notes | For this review, we compared group B with group C. and group A with group D. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Quote: "....randomized,..." Comment: insufficient information to permit judgment. |
Allocation concealment (selection bias) | Unclear risk | Insufficient information to permit judgment. |
Blinding (performance bias and detection bias) All outcomes | Low risk | Quote: "....double blind,..." |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Insufficient information to permit judgment. |
Selective reporting (reporting bias) | Unclear risk | Insufficient information to permit judgment. |
Other bias | Unclear risk | No other bias identified but insufficient information available to fully assess this 'Risk of bias' domain. |