Iyengar 1975.
Methods | This RCT was conducted in Niloufer Hospital, Hyderabad (India). Women were alternatively assigned to treatment groups. Groups were matched on parity and height. The women were followed at monthly intervals until 32 weeks of gestation, once every 2 weeks until 36 weeks, and at weekly intervals thereafter until delivery. | |
Participants | Pregnant women between 20 and 28 weeks of gestation (n = 288). | |
Interventions | Group 1: no supplement (n = 52), Group 1: iron 60 mg (n = 96), Group 2: iron 60 mg + folic acid 500 µg (n = 134). | |
Outcomes | Birthweight (n = 230). | |
Notes | Pregant women belonging to low income less than Rs. 3000/‐ per month. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | High risk | Quote: "alternate subjects received either of therapy". Comment: probably not done. |
Allocation concealment (selection bias) | Unclear risk | Insufficient information to permit judgement regarding allocation concealment. |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Insufficient information to permit judgement regarding blinding. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Exclusion data with their reasons were not reported in the study. Attrition (> 20%) along with reasons were reported. |
Selective reporting (reporting bias) | Low risk | Study seems to be free from selective reporting. |
Other bias | Unclear risk | No other bias identified but insufficient information available to fully assess this 'Risk of bias' domain. |