Rae 1970.

Methods	This was a RCT. Randomisation was done according to a day of week on which women coming for antenatal clinic in Liverpool (UK). Samples of venous blood were taken from patients in both groups at the first visit to the antenatal clinic, at the 32nd and 36th weeks of pregnancy, and during the first 3 days of puerperium.
Participants	Pregnant women coming for antenatal visits (n = 698).
Interventions	Pregnant women coming on Monday was assigned were prescribed ferrous gluconate 200 mg, while those coming in Tuesday were given same dose of ferrous gluconate in addition to a folic acid 5 mg. Monday group (n = 463) and Tuesday group (n = 235), total (n = 698).
Outcomes	Low pre‐delivery anaemia (< 10.9 g/dL) (n = 698), megaloblastic anaemia (n = 698).
Notes	Patients with a haemoglobin concentration of 10.9 g/dL or more were classified 'not anaemic', and those with a haemoglobin concentration of under 10.9 g/dL were classified 'normoblastic' or 'megaloblastic' according to the marrow smear.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Quote: "patients were allocated at random to one or other of the two groups, depending on which day of the week they attended the antenatal clinic". Comment: probably not done.
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information to permit judgement.
Selective reporting (reporting bias)	Low risk	The study has mentioned data on all outcome measures mentioned as objectives.
Other bias	Unclear risk	No other bias identified but insufficient information available to fully assess this 'Risk of bias' domain.