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. 2023 Mar 30;13(3):e066987. doi: 10.1136/bmjopen-2022-066987

Table 1.

Inclusion and exclusion criteria

Inclusion criteria Exclusion criteria

  • Diagnosis of fibromyalgia.

  • Women aged 20–70 years.

  • Swedish-speaking.

  • Safe method of contraception.

  • Cobalamin value >250 pmol/L < 800 pmol/L.

  • Kidney function value (relatively) GFR >60 .mL/min/1.73 m2.

  • Liver function value.

    • P-ALP 0.6–2.85 µkat/L.

    • P-ALAT 0.15–1.13 µkat/L.

  • Heart function value.

  • Troponin-T <15 ng/L.

    • NT-pro-BNP.

    • <60 years <125 ng/L.

    • NT-pro-BNP.

    • 60 years <300.

    • Given consent to participate.

  • Previous treatment with B12.

  • Known hypersensitivity to the active substance. mecobalamin or an additive.

  • Neuroleptic treatment.

  • Reynaud’s phenomenon.

  • Known neuropathy.

  • Vegan as veganism can lead to B12 deficiency.

  • Known heart, kidney or liver disease.

  • Breast feeding.

  • Planned or ongoing pregnancy.