Fig. 2.

Relationship of in silico score for CAD (ISCAD) with coronary stenosis and atherosclerosis complexity on cardiac catheterization.

Cardiac catheterization data were examined for association with ISCAD. This comprised percent coronary stenosis, recorded as 7 strata ranging from [0, 30), less than 30%, to [100], 100%, and SYNTAX score ranging from 0, low complexity, to 30, high complexity. ISCAD were stratified by quartiles. a, Individuals who underwent cardiac catheterization (red) had higher mean ISCAD (dashed line) than those who had not underwent cardiac catheterization (purple). b, Violin plots show the distribution of samples across coronary stenosis values along with the mean value overlaid as a point for each ISCAD quartile. c, Violin plots show the distribution of samples across SYNTAX score values along with the mean value overlaid as a point for each ISCAD quartile. d, Schematic of coronary arteries depicts the association of ISCAD with obstructive CAD (≥50% stenosis in the left main coronary artery, ≥70% stenosis in any other coronary artery, or both), multivessel CAD (≥70% stenosis in at least two coronary arteries, or ≥50% stenosis in left main coronary artery and ≥70% stenosis in another coronary artery), left main stenosis (≥50%), proximal left anterior descending (LAD) stenosis (≥70%), left circumflex stenosis (≥70%), and right coronary artery stenosis (≥70%). Results are reported as adjusted odds ratio (95% CI) P value per increase in ISCAD quartile.