Table 2.

Training and testing data for identification of predictive risk groups for stricturing disease using summed deleteriousness across the whole gene (GenePy score). Performance of the cutoffs derived from training data is shown in the test data.

Groupsa	NOD2 CADD >15 Variants (training set = 484)			NOD2 CADD >15 Variants (testing set = 161)
	Absolute Cut Off Value of GenePy Scorea	Number of Patients in Group (%)	Number of Stricturing Patients in Group	Absolute Cutoff Values	Number of Patients in Group (%)	Number of Stricturing Patients in Group
Group 1 (high risk)	≥1.078	59 (12.2%)	27 (45.7%)	≥1.078	30 (18.6%)	17 (56.7%)
Group 2 (low risk)	<1.078	425 (87.8%)	108 (25.4%)	<1.078	131 (81.4%)	28 (21.4%)

^aGroups determined by Fisher exact test.