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. 2022 Sep 6;25(2):184–191. doi: 10.4103/aja202255

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Relationship among exogenous factors, endogenous factors, circadian rhythm and PCa. Changes in endogenous factors and exogenous factors are both involved in the disruption of circadian rhythm, which is potentially related to PCa. Alternations in circadian rhythm also impact endogenous and exogenous factors. In addition, alternations in the lifestyle of exogenous factors, including night-shift work, changes in sleep patterns and intermittent fasting, play a role in aging and endocrine disturbance. PCa: prostate cancer.