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. 2023 Feb 20;34(3):345–352. doi: 10.1097/EDE.0000000000001603

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Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 1. — Averted hospitalizations in adults ≥65 under different trade-off scenarios. Bars indicate the mean number (A) and percentage relative to baseline (B) of averted hospitalizations from 1,000 uniform Latin hypercube parameter combinations; error bars are the 95th percentiles. Each panel shows a different combination of the delay in administration of additional higher-dose or adjuvanted vaccines (0, 3, or 6 weeks), and reduction in overall vaccine coverage (0, 10, or 20 percentage points). Positive values indicate a decrease in burden relative to the corresponding baseline simulation and therefore a positive impact of the new recommendation. Results for the number of averted symptomatic cases and deaths are shown in eFigure 8, http://links.lww.com/EDE/C18, and results assuming a logit-normal distribution for rVE with a median value of 15% are shown in eFigure 12, http://links.lww.com/EDE/C18. rVE indicates relative vaccine effectiveness.