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. 2023 Feb 20;34(3):345–352. doi: 10.1097/EDE.0000000000001603

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Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

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FIGURE 2. — The reduction in overall vaccine coverage has the greatest impact on predicted outcomes. One-way (A) and two-way (B) sensitivity analyses assessing the impact of key parameters on the number of hospitalizations averted in adults ≥65. Positive values indicate a positive number of hospitalizations were averted relative to the corresponding baseline simulation and thus the new recommendation had a positive impact (i.e., reduced the total number of hospitalizations). Parameter ranges are given in eTable 1, http://links.lww.com/EDE/C18. In (B), rVE is 15%, 75% of vaccinees ≥65 receive an HDAV at baseline, and there is a 10 percentage point increase in HDAV uptake following the new recommendation. rVE indicates relative vaccine effectiveness and HDAV indicates higher-dose or adjuvanted vaccine.