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. 2022 Apr 7;145(24):1764–1779. doi: 10.1161/CIRCULATIONAHA.121.058489

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© 2022 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Violine plots representing the distribution of hs-cTnT/I concentrations for the 4 tested assays and across categories of cardiac disease. A single comparison using a Mann-Whitney U test was conducted between the control subjects of the APACE (Advantageous Predictors of Acute Coronary Syndromes Evaluation) cohort and the overall cohort of patients with skeletal muscle disorder. Bioequivalent and overall approved upper limits of normal (ULNs) are represented as broken lines. High-sensitivity cardiac troponin T (hs-cTnT)–Elecsys and high-sensitivity cardiac troponin I (hs-cTnI)–Architect concentrations were available in all 211 patients; hs-cTnI–Access concentrations, in 187 patients; and hs-cTnI–Vista concentrations, in 194 patients. The P values were calculating with a Wilcoxon test comparing the overall group with the control group and have been corrected for multiple testing (4 tests) with the Benjamini and Hochberg method.