Figure 3.

NLRP3 inhibition decreased renal vascular resistance in placental ischemic rats and improved uterine artery function. Results of UARI (A) as measured via Doppler sonography, renal blood flow measurements (B), and renal vascular resistance measurements (C). NLRP3 inhibition did not improve kidney injury in placental ischemic rats. E: glomerular filtration rate was measured via FITC sinistrin clearance. Results of glomerular injury (F) and renal fibrosis (G) scored in periodic acid Schiff (PAS) stained, paraffin-embedded kidney sections. Data were presented as means ± SD. *P < 0.05 vs. NP + Vehicle, #P < 0.05 vs. RUPP + Vehicle, n = 4–9. NP, normal pregnant; RUPP, reduced uterine perfusion pressure; UARI, uterine artery resistance index.