Table 1.

iMCD main clinical manifestations

Fever

Weight loss

Generalized lymphadenopathy, usually of relatively small volume

Splenomegaly (which may be massive) and, in some cases, hepatomegaly

Anaemia (other cytopenias may be present)

Hypoalbuminaemia

Elevations in inflammatory markers

Anasarca

Intravascular depletion and renal impairment