Table 2.
Mendelian randomisation results of lipid traits with risk of non-alcoholic fatty liver disease.
| Lipid trait | Methods | NAFLD (discovery dataset) |
NAFLD (replication dataset) |
||
|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | ||
| TG | Inverse variance weighted | 1.131 (1.018, 1.256) | 0.02 | 1.007 (0.921, 1.102) | 0.87 |
| Weighted median method | 1.141 (0.959, 1.357) | 0.14 | 0.962 (0.851, 1.087) | 0.54 | |
| Weighted mode method | 1.170 (0.949, 1.443) | 0.15 | 0.965 (0.263, 3.543) | 0.96 | |
| MR-PRESSO | 1.167 (1.016, 1.341) | 0.03 | 0.981(0.876, 1.098) | 0.74 | |
| LDL-C | Inverse variance weighted | 0.967 (0.901, 1.036) | 0.33 | 0.998 (0.908, 1.096) | 0.97 |
| Weighted median method | 1.003 (0.905, 1.112) | 0.95 | 1.006 (0.877, 1.154) | 0.93 | |
| Weighted mode method | 0.996 (0.907, 1.094) | 0.94 | 1.026 (0.779, 1.353) | 0.85 | |
| MR-PRESSO | 0.980 (0.898, 1.069) | 0.65 | 1.125 (0.909, 1.011) | 0.84 | |
| TC | Inverse variance weighted | 0.944 (0.875, 1.018) | 0.13 | 1.016 (0.913, 1.129) | 0.78 |
| Weighted median method | 0.974 (0.853, 1.111) | 0.69 | 1.007 (0.865, 1.173) | 0.93 | |
| Weighted mode method | 0.973 (0.877, 1.079) | 0.60 | 1.008 (0.798, 1.275) | 0.94 | |
| MR-PRESSO | 0.960 (0.868, 1.061) | 0.42 | 1.012 (0.900, 1.138) | 0.84 | |
Abbreviations: LDL-C, low density lipoprotein cholesterol; TG, triglyceride; TC, total cholesterol; SNP, single-nucleotide polymorphisms; CI, confidence interval.