In A, WT and Cc16–/– mice were exposed to air or CS for a total of 24 weeks, receiving rhCC16 protein weeks 12–24. In B, WT and Cc16–/– mice were exposed to air or CS for a total of 5 weeks, receiving rhCC16 protein from week 3 through week 5. In C, WT and Cc16–/– mice were exposed to air or CS for a total of 8 weeks, receiving rhCC16 protein from week 4 through week 8. In D, WT and Cc16–/– mice were exposed to air or CS for a total of 12 weeks, receiving NF-κB inhibitor from week 6 through week 12. The readouts measured for each exposure are indicated. Foxj1, Forkhead box-J1.