Skip to main content
. 2023 Mar 22;8(6):e130771. doi: 10.1172/jci.insight.130771

Figure 6. Treating CS-exposed Cc16–/– mice with rhCC16 reduces chronic pulmonary inflammation.

Figure 6

WT and Cc16–/– mice were exposed to air (7–8 mice/group) or CS for 24 weeks (20–25 mice/group). CS-exposed mice were treated with rhCC16 (75 μg of rhCC16; 10–15 mice/group) or vehicle (10–13 mice/group) thrice weekly for the last 12 weeks of the exposures and BAL was performed. BAL total leukocytes (A), macrophages (B), PMNs (C), and lymphocytes (D) were counted. Boxes in the box plots show the median values and 25th and 75th percentiles, and whiskers show the 10th and 90th percentiles. Data were analyzed using 1-way ANOVAs followed by pairwise testing with Mann-Whitney U tests. Asterisks indicate P < 0.05 vs. air-exposed mice belonging to the same genotype or the group indicated.