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In the tumor, NRF2 inhibitors help suppress tumor growth and metastasis by decreasing NRF2 protein levels. In addition, synthetic lethality anti-cancer drugs are transformed into strongly active drugs by NRF2-targeted drug-metabolizing enzymes. In contrast, activation of NRF2 in the microenvironment inhibits the progression of NRF2-overactivated malignant tumors. NRF2, NF-E2-related factor 2.
